Typical wastewater treatment plants are designed to treat multiple pollutants, including organic carbon from human and food waste; nutrients like nitrogen and phosphorus; and pathogenic bacteria and viruses that cause disease. However, they are not equipped to handle the many ingredients of concern that are present in personal care products. Protecting the environment and human health from these substances will require progress in several areas. They include improving technologies for wastewater treatment plants; conducting more testing and regulation of personal care products to avoid unintended toxicity to aquatic animals; and designing “green chemicals” that do not pose toxicity concerns. This multi-pronged approach will help us to ensure that personal care products continue to improve our quality of life without harming the environment.